Patients with moderate-to-severe atopic dermatitis (AD) have an increased prevalence of hypertension compared with patients who do not have AD, according to a recent study, the results of which were published as part of the American Academy of Dermatology Virtual Meeting Experience 2020.
Researchers conducted a systematic review of all published studies in Medline, Embase, Scopus, Web of Science, and Global Resource for Eczema Trials databases. At least two reviewers independently performed study title and abstract review and data extraction, and a pooled random-effects meta-analysis of the proportion of hypertension in patients with and without AD was performed. A total of 47 studies were included in the analysis.
Patients with AD had significantly higher odds of hypertension (18.1%) compared with healthy controls (15.3%; pooled odds ratio [OR], 1.16; 95% confidence interval [CI], 1.04-1.30; P<0.001).
However, AD was associated with a significantly lower prevalence and odds of hypertension compared with patients with psoriasis (15.4% vs. 24.9%; pooled OR, 0.53; 95% CI, 0.37-0.76; P<0.001).
In particular, moderate-to-severe and severe AD was associated with significant differences of hypertension (24.0% vs. 13.9%; OR, 2.46; 95% CI, 1.06-5.68; P<0.001), while mild AD was not associated with hypertension (17.9% vs. 18.2%; OR, 0.98; 95% CI, 0.83-1.15; P=0.033).
Further studies are needed to confirm this relationship, the authors noted.
Yousaf Y, Ayasse M, Ahmed A, et al. The Association between Atopic Dermatitis and Hypertension: A Systematic Review and Meta-Analysis. Abstract 2556. Presented during the AAD Virtual Meeting Experience 2020, June 12-14, 2020.